One of the most fundamental property of a new chemical entity which determines its future as a drug formulation, is its water solubility and hence its bioavailability. A large number of NCEs during development today face the problem of being poorly water soluble. The editors have put together a wealth of material derived from experienced authors in the field of pharmaceutical sciences and manufacturing in this book. The book starts of by elaborating the problem of solubility and the significance of the same in new drug development. It stresses on the oral, parenteral and the pulmonary route of administration of these drugs.
Chapter 2 explains the various parameters and tests performed to test the solubility of a chemical entity and hence characterisation of the problem. Chapters 3 – 13 describe in detail the various methods adopted in order to improve solubility namely salt selection, particle size reduction, co-solvent selection, cyclodextrin complexes, gelatin dosage forms, liposomal parentral formulations, self-emulsifying lipid formulations, development of amorphous systems, etc. The final conversion into dosage forms via melt extrusion and spray drying techniques are explained in dedicated chapters. The book ends by devoting a chapter on quality control, regulations and upscaling of these techniques in the industry. Each chapter is made simpler with flow diagrams, graphs, illustrations and pictures. A must have book for every pharmacuetical scientist, pharmacist, regulator, student and enterprenuer.
Editors: Robert O Williams III, Alan B Watts, Dave A Miller
Price: Rs 16,182
Publisher: AAPS press
Distributor: Wisdom Book Distributors,HornbyBuilding, 1st Floor, 174, D N Road, Mumbai 400 001
Tel: 022 2207 4484/6631 8958,
Telefax: 022-2203 4058
Email: thadam@vsnl.com
Reviewer: Dr Mandar Kubal, Director, Infectious Diseases & Pulmonary Care Pvt Ltd
